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Research and Development - Iowa City VA Health Care System

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Biomedical Laboratory Research Funding Awards to VA Research Service Investigators

The Biomedical Laboratory Research Service of the Department of Veterans Affairs Office of Research and Development funds and administers research that focuses on the diagnosis and treatment of a wide range of diseases and disorders affecting veterans. The primary goals of the Service are twofold: to support high quality biomedical research relevant to veterans' health care needs and to develop and enhance the research environment. The Research Office wishes to recognize these scientists who were awarded grants that began October 1, 2004.

Principle Investigator Grant Title Goals of Study
Mark W. Chapleau, Ph.D. Oxidant Stress-Induced Autonomic/Baroreflex Dysfunction in Heart Failure Decreased baroreflex sensitivity is a strong predictor of death post myocardial infarction ( MI ). While the importance of oxidative stress in cardiac and vascular dysfunction post- MI is established, its impact on autonomic/baroreflex function remains relatively unexplored. The results of this study may impact on the design of antioxidant therapies.
Ulla Kopp, Ph.D. Afferent Renal Nerves: Role of Neurotransmitters This study will identify abnormalities in the activation of renal sensory nerves and renorenal reflexes. The results of this work may permit the development of new and more efficacious therapies for prevention, and treatment of hypertension.
John H. Lee, M.D. Therapeutic Potential of HPV -16 E6 and E7 Inhibition Human papillomavirus ( HPV ) is a known factor in the causation of cervical cancer and head and neck cancer. This study will shed more light on HPV biology hopefully leading to the development of new clinical treatment protocols.
Konrad S. Schulze, M.D. Mechanics of Stomach and Intestine Modern imaging methods (fact CT and MRI scanning, etc.) hold promise for the clinical diagnosis of abnormal gastro-intestinal motility. This study will develop a means for identifying the visual parameters needed for modern imaging to be utilized.
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